Severe Combined ImmunoDeficient (SCID) mice in biomedical research
نویسندگان
چکیده
منابع مشابه
Adriamycin nephropathy in severe combined immunodeficient (SCID) mice.
Experimental focal glomerulosclerosis is a model of chronic proteinuric renal disease that has been induced in both rats and mice. In mice, the adriamycin (ADR)induced nephropathy model is a robust experimental analogue of human focal glomerulosclerosis [1]. Renal injury in the ADR-induced nephropathy model is characterized by changes in both the tubulointerstitial and glomerular compartments. ...
متن کاملExacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice.
The immune system functions to protect an organism against microbial infections and may be involved in the reparative response to nerve injury. The goal of this study was to determine whether the immune system plays a role in regulating motoneuron survival after a peripheral nerve injury. After a right facial nerve axotomy, facial motoneuron (FMN) survival in C.B-17 (+/+) wild-type mice was fou...
متن کاملImproved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes
We have generated immunodeficient scid-/scid- (SCID)-transgenic mice expressing the genes for human interleukin 3, granulocyte/macrophage-colony stimulating factor, and stem cell factor. We have compared engraftment and differentiation of human hematopoietic cells in transgenic SCID mice with two strains of nontransgenic SCID mice. Human bone marrow cells carrying the CD34 antigen or human umbi...
متن کاملTransfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice
To study the role of peripheral blood leukocytes (PBL) in the pathogenesis of human systemic lupus erythematosus (SLE), we transferred PBL from 5 SLE patients into 15 severe combined immunodeficiency (SCID) mice. Such reconstituted mice showed long-term presence of auto-antibodies characteristic of the donor in their sera, as well as human immunoglobulin deposition, and in some cases mouse C3, ...
متن کاملGeneration of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice
Human PBL have been reported to reconstitute B and T cells as well as human serum Ig in mice with severe combined immunodeficiency disease (SCID). To confirm these observations and attempt the transfer of an autoimmune disease to the immunodeficient animals, groups of SCID mice received an injection of PBL from patients with primary biliary cirrhosis (PBC) or from normal volunteers. By 8 wk aft...
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ژورنال
عنوان ژورنال: Journal of the Hellenic Veterinary Medical Society
سال: 2017
ISSN: 2585-3724,1792-2720
DOI: 10.12681/jhvms.14937